Anti-UBE2E3 Antibody

This unconjugated rabbit polyclonal IgG antibody from Antibodies.com targets UBE2E3, a ubiquitin-conjugating enzyme of the E2 family involved in cellular protein ubiquitination and proteasome-mediated degradation. The reagent is supplied as 200 µl of polyclonal antiserum and is validated for Western blot and immunohistochemistry workflows against human and mouse samples.

UBE2E3 participates in the ubiquitin-proteasome system, contributing to post-translational protein modification, cell cycle regulation, and the DNA damage response. Published studies have linked UBE2E3 variants to insulin signaling and type 2 diabetes susceptibility, as well as to cognitive function in mammalian models, making this reagent useful for laboratories exploring metabolic disease mechanisms, neurodegeneration, and basic cell biology.

Recommended storage is at -20 °C in working aliquots to limit freeze-thaw cycles, and the vial contents should be protected from light during handling. Researchers commonly apply the antibody to whole-cell lysates and tissue sections to assess endogenous UBE2E3 expression across a range of experimental systems, including immunoblotting of cultured mammalian cell extracts and IHC staining of formalin-fixed paraffin-embedded tissue.