Anti-UBE2D2 Antibody

Polyclonal antibody reagent from Antibodies.com targets UBE2D2, a ubiquitin-conjugating enzyme (E2) that partners with E3 ligases such as MDM2 and CHIP to transfer activated ubiquitin onto substrate proteins destined for proteasomal turnover. The antibody is raised in rabbit and supplied unconjugated as 100 µl of a 1 mg/ml stock in PBS containing 0.1% sodium azide and 50% glycerol, a glycerol-rich formulation that resists freeze-thaw damage during repeated experimental cycles. Validated uses include western blot for expression profiling and immunocytochemistry for subcellular localization across human, mouse, and rat samples, supporting research into p53 regulation, DNA damage response signaling, and broader ubiquitin-proteasome pathway biology. Investigators frequently deploy this reagent to compare UBE2D2 levels in transformed versus normal cell lines, to immunoprecipitate interacting partners from lysates, and to map E2 distribution in fixed tissue sections where altered ubiquitination contributes to disease phenotypes.