Anti-UBB Antibody

Ubiquitin B is the protein product of the UBB gene, one of four mammalian loci encoding the small regulatory protein ubiquitin. Antibodies.com offers a rabbit polyclonal primary antibody raised against Ubiquitin B, supplied unconjugated in a 100 µl vial and validated for Western Blot (WB) and Immunohistochemistry (IHC) workflows. Ubiquitin B participates in the ubiquitin-proteasome system, where it is conjugated to substrate proteins as a post-translational modification that marks them for degradation, alters subcellular localization, or modulates their activity in pathways such as cell-cycle progression, DNA damage repair, and cellular stress response.

The reagent shows reactivity with Human and Mouse samples, supporting cross-species studies in cell lysates and fixed tissue sections. Its polyclonal format enables recognition of multiple epitopes on Ubiquitin B, which is helpful when investigating protein turnover, polyubiquitin chain dynamics, and steady-state ubiquitin levels. Altered UBB expression has been linked to neurodegenerative disease models and several cancer contexts, making this antibody useful for research into proteostasis, neurodegeneration, and tumor biology. Store refrigerated at 2 to 8 degrees C and protect from light to preserve reagent performance.