Anti-UBB Antibody

UBB encodes Ubiquitin B, a highly conserved 76-amino-acid protein that is covalently attached to lysine residues on substrate proteins as part of the ubiquitin-proteasome system. This rabbit polyclonal IgG antibody, supplied by Antibodies.com as an unconjugated reagent in a 50 µl volume, is raised against UBB and validated for Western blot detection of the endogenous protein in human, mouse, and rat samples. It is intended for research use only.

Researchers studying protein degradation, post-translational modification by ubiquitination, or aggregate clearance in neurodegeneration models use this reagent to monitor steady-state ubiquitin levels and polyubiquitin chain accumulation in cell lysates and tissue homogenates. The polyclonal format provides recognition of multiple epitopes across the UBB sequence, which can be useful when working with denatured, reduced samples on SDS-PAGE.

For best results, store the antibody refrigerated at 4°C in working aliquots to limit freeze-thaw cycles and protect the IgG preparation from loss of activity over time.