Anti-UBAP1 Antibody

The UBAP1 target (Ubiquitin-Associated Protein 1) is a subunit of the ESCRT-I endosomal sorting complex required for recognition and trafficking of ubiquitinated cargo proteins. Loss-of-function mutations in UBAP1 cause hereditary spastic paraplegia type 80 (SPG80), and altered UBAP1 expression has been reported in several cancer contexts, making the protein relevant to neurodegeneration research and oncology studies of ubiquitin-dependent protein degradation.

From Antibodies.com, this unconjugated rabbit polyclonal IgG reagent is supplied as 200 µl and validated for western blot, immunohistochemistry, and flow cytometry. The polyclonal host format yields multi-epitope recognition, helpful when working with post-translationally modified targets or truncated isoforms that may evade monoclonal capture. Reactivity has been confirmed in human and mouse samples, supporting cross-species experimental design across cell line panels and primary tissue.

For assay setup, dilute the unconjugated IgG according to your standard protocol and aliquot to limit freeze-thaw cycles; the unconjugated format allows direct conjugation to fluorophores or HRP within the laboratory. Storage at -20 °C is recommended for the 200 µl volume.