Anti-UBAP1 Antibody

This polyclonal reagent from Antibodies.com targets UBAP1 (Ubiquitin-Associated Protein 1), a core component of the ESCRT-I complex that recognizes ubiquitinated cargo and directs its sorting into multivesicular bodies for lysosomal degradation. Raised in rabbit and supplied as an unconjugated IgG preparation at 100 µl, the antibody is validated for Western blot, immunohistochemistry, and flow cytometry across Human and Mouse samples. UBAP1 has emerged as a target of clinical interest because loss-of-function variants in the gene have been linked to hereditary spastic paraplegia (SPG80), making the reagent relevant for proteostasis, neurobiology, and endosomal trafficking research. The ESCRT-I complex, in which UBAP1 operates alongside subunits such as TSG101, governs early endosome maturation and the turnover of membrane-associated ubiquitinated proteins; researchers therefore use this antibody to probe recruitment dynamics, complex assembly, and substrate recognition in cell-based and tissue-based assays. The unconjugated format gives laboratories the flexibility to conjugate the antibody themselves with fluorophores, enzymes, or biotin to suit downstream detection chemistries without altering the underlying polyclonal reactivity profile.