Anti-UBA1 Antibody

UBA1 (ubiquitin-activating enzyme E1) catalyzes the first step of the ubiquitin–proteasome cascade, activating ubiquitin in an ATP-dependent manner and transferring it to E2 conjugating enzymes. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against UBA1 and validated for Western blot and ELISA workflows across human, mouse, and rat samples. Supplied as 100 µl of polyclonal serum from a rabbit host, the antibody supports detection of endogenous E1 in cell lysates, tissue extracts, and recombinant preparations. UBA1 expression is of particular interest in studies of protein homeostasis, DNA damage response, and inflammatory disease research, including recent investigations into X-linked VEXAS syndrome, where somatic UBA1 mutations drive severe autoinflammatory phenotypes.