Anti-Tyrosine Hydroxylase (Ab-19) Antibody

Tyrosine Hydroxylase (TH) is the rate-limiting enzyme that converts L-tyrosine to L-DOPA in the catecholamine biosynthesis pathway, and reliable antibodies against it are essential tools in neuroscience research. This polyclonal primary antibody from Antibodies.com, raised in rabbit against the TH antigen, is supplied in unconjugated 100 µl vials and validated for Western blot, immunohistochemistry, and immunofluorescence applications across Human, Mouse, and Rat samples.

TH expression is widely used as a marker for catecholaminergic neurons, including dopaminergic neurons in the substantia nigra and ventral tegmental area, as well as noradrenergic neurons in the locus coeruleus. The enzyme is also abundant in chromaffin cells of the adrenal medulla and in several neuroendocrine tissues, which makes anti-TH reagents informative for studies of Parkinson's disease models, addiction-related circuits, stress responses, and the characterization of pheochromocytoma and neuroblastoma cell lines.

The unconjugated format supports both chromogenic and fluorescence-based detection when paired with appropriate secondary antibodies. Researchers routinely apply this reagent to brain tissue sections, adrenal gland preparations, cultured neuronal lines, and total protein extracts. For long-term stability, store the antibody at -20 °C in working aliquots and limit freeze-thaw cycles to preserve binding activity.

Format: 100 µl vial, unconjugated, polyclonal.