Anti-Type II 5-phosphatase Antibody

Raised in rabbit against the inositol polyphosphate 5-phosphatase type II (INPP5B), this polyclonal reagent from Antibodies.com recognizes a Golgi-associated phosphatase that hydrolyzes the 5-phosphate of phosphatidylinositol 4,5-bisphosphate and related phosphoinositide substrates. INPP5B contributes to phosphoinositide turnover at the Golgi membrane, supporting vesicle trafficking, signal termination downstream of phospholipase C, and the maintenance of compartment-specific lipid identity in human cells.

The unconjugated preparation is supplied at 100 µl and validated for Western blot and immunohistochemistry on human samples. Because the reagent is unconjugated, laboratories can pair it with HRP, biotin, or fluorescent labels of their choice, adapting it to chromogenic IHC, immunofluorescence, or standard immunoblotting workflows.

Reactivity is reported for human specimens, and the polyclonal format offers broader epitope coverage than monoclonal alternatives, useful when probing the conserved catalytic domain shared among 5-phosphatase family members. For working use, aliquot and store refrigerated; longer-term frozen storage is recommended to preserve activity across freeze-thaw cycles.