Anti-TYK2 Antibody

Tyrosine Kinase 2 (TYK2) sits at the head of the JAK-STAT signaling cascade, pairing with type I interferon, IL-12, IL-23, and IL-10 receptor complexes to drive STAT-dependent transcription. This rabbit polyclonal antibody from Antibodies.com is raised against TYK2 and supplied as an unconjugated reagent at 100 µl, validated for Western blot and immunofluorescence on human samples. Researchers use it to profile JAK-STAT pathway activity, track cytokine responses, and characterize loss-of-function TYK2 variants associated with autosomal recessive primary immunodeficiency. The polyclonal format recognizes multiple epitopes across the target, which helps when comparing full-length and truncated isoforms or monitoring expression shifts following IFN or IL-12 stimulation. Aliquot upon first thaw, store at -20 °C in a frost-free freezer, and limit repeated freeze-thaw cycles to preserve titer; for active bench work, keep the vial on ice and shield from light.