Anti-Tyk 2 Antibody

Raised in rabbit, this unconjugated polyclonal reagent recognizes Tyrosine Kinase 2 (Tyk 2), a member of the Janus kinase family that couples type I interferon and IL-12/IL-23 cytokine receptors to downstream STAT signaling in immune cells. Distributed by Antibodies.com, the antibody is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows and shows reactivity against human, mouse, and monkey samples, supporting comparative studies of JAK-STAT pathway activation across species.

Tyk 2 sits at a well-studied node in cytokine-driven immunity, and loss-of-function variants in the gene are linked to primary immunodeficiency, making reliable detection relevant for immunology, inflammation, and signal transduction research. The 100 µl vial format suits multi-assay use, and the unconjugated format lets each lab pair it with a preferred secondary reporter. Store refrigerated and protect from light; aliquot to limit freeze-thaw cycles and centrifuge briefly before use to recover full volume.

Typical applications include western blot analysis of Tyk 2 phosphorylation and expression in stimulated cell lysates, immunofluorescence imaging of subcellular distribution in cultured immune cells, and immunohistochemistry on paraffin-embedded tissue sections to map receptor-associated kinase expression in disease models.