Anti-TXNRD2 Antibody

This unconjugated rabbit polyclonal reagent targets mitochondrial thioredoxin reductase 2 (TXNRD2), a selenocysteine-containing flavoenzyme that sustains cellular redox homeostasis by reducing thioredoxin and supporting the mitochondrial antioxidant defense network. Produced by Antibodies.com as a primary antibody reagent, the antiserum is supplied as 100 µl aliquots and is validated for two core workflows: Western blot analysis of protein expression across cultured cells and tissue lysates, and immunohistochemistry on formalin-fixed paraffin-embedded sections.

Reactive with the human, mouse, and rat orthologs, the reagent supports cross-species comparative studies of mitochondrial oxidative stress responses, including cardiomyocyte protection models, neurodegeneration paradigms, and tumor biology investigations where TXNRD2 expression often correlates with proliferation and drug-resistance phenotypes. Because thioredoxin reductase 2 sits at the intersection of mitochondrial ROS scavenging, DNA synthesis support, and survival signaling, researchers deploy this antibody to examine mitochondrial dysfunction, ischemia-reperfusion injury, and redox-based therapeutic strategies. The polyclonal format provides recognition of multiple epitopes within the TXNRD2 sequence, which can improve detection in samples where the target is expressed at low copy number.

Storage follows standard antibody handling: aliquot upon receipt and store frozen at -20 degrees C or below to preserve activity across cycles, avoiding repeated freeze-thaw of the working vial. For research use only; not intended for diagnostic or therapeutic procedures.