Anti-TUBB8 Antibody

This rabbit polyclonal antibody from Antibodies.com targets TUBB8 (tubulin beta-8 chain), a beta-tubulin isotype most strongly expressed in oocytes and preimplantation embryos, where it supports meiotic and mitotic spindle assembly. The reagent is supplied as 50 µl of unconjugated IgG in a vial and is validated for Western blot, immunofluorescence, and immunohistochemistry workflows. It recognizes the human TUBB8 protein and cross-reacts with mouse and rat orthologs, enabling studies in rodent models of oocyte maturation and cleavage-stage embryo development. Loss-of-function mutations in TUBB8 have been linked to human oocyte maturation arrest and zygote cleavage failure, so this antibody is useful for reproductive biology and infertility research investigating spindle organization, chromosomal segregation, and early embryogenesis. Aliquot upon arrival, refrigerate the working stock, and avoid repeated freeze-thaw cycles to preserve activity.