Anti-TUBA4A Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com targets TUBA4A, the alpha-tubulin 4A chain that serves as a core building block of microtubules in dividing and non-dividing cells. The reagent is supplied as a 50 µl liquid aliquot and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows, supporting studies of cytoskeletal organization, intracellular transport, and mitotic spindle assembly.

Researchers investigating neurodegeneration use TUBA4A antibodies to probe pathogenic variants linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, where missense mutations disrupt tubulin heterodimer folding and microtubule stability in upper and lower motor neurons. Demonstrated reactivity with Human, Mouse, and Rat samples enables parallel comparison between patient-derived iPSC lines, transgenic mouse models, and rat tissue sections on a single blot or slide. For long-term use, store the vial at -20 °C in single-use aliquots to preserve polyclonal reactivity across multiple freeze-thaw cycles.