Anti-TTR Antibody

The transthyretin (TTR) protein is the target of this rabbit polyclonal primary antibody from Antibodies.com, supplied as 100 µl of unconjugated antiserum validated for Western blot (WB) and immunohistochemistry (IHC) workflows. The reagent shows reactivity with Human, Mouse, and Rat samples, supporting translational studies that span rodent disease models and human clinical specimens.

Transthyretin is a 55 kDa homotetrameric carrier protein responsible for transporting thyroxine and vitamin A (via retinol-binding protein) in plasma and cerebrospinal fluid. It is widely investigated in the context of familial amyloid polyneuropathy, hereditary transthyretin amyloid cardiomyopathy, and wild-type senile systemic amyloidosis, where point mutations such as V30M destabilize the tetramer and drive fibril deposition in peripheral nerves and the heart. Researchers also rely on anti-TTR detection to probe choroid plexus function, hepatic secretory output, and CSF protein composition in neuroscience and hepatology studies, where strong signal in the epithelial lining of the ventricles and in hepatocytes is routinely reported.

The unconjugated format allows flexible pairing with HRP, biotin, or fluorophore-conjugated secondary antibodies chosen to suit a given imaging, blotting, or chromogenic detection assay. Recommended handling includes brief centrifugation upon arrival, refrigerated storage for short-term use, and aliquotting for freezing at -20 °C to limit freeze-thaw cycles and preserve polyclonal antibody titer over multiple experiments. The product is intended for research use only and is not approved for diagnostic or therapeutic applications.