Anti-TTLL1 Antibody

TTLL1 (Tubulin Tyrosine Ligase-Like 1) is a tubulin polyglutamylase that initiates post-translational addition of glutamate side chains onto tubulin C-terminal tails. This modification is essential for stable assembly of motile and sensory cilia, intraflagellar transport, and microtubule-based signaling in neurons and photoreceptors. Investigators focused on cytoskeletal regulation, ciliogenesis, and neuronal differentiation use anti-TTLL1 reagents to profile endogenous protein levels in human cells and tissues.

This unconjugated rabbit polyclonal antibody from Antibodies.com is validated for Western blot and immunohistochemistry on human-derived samples. The reagent recognizes the native TTLL1 protein in whole-cell lysates and in formalin-fixed tissue sections, supporting both quantitative expression analysis and subcellular localization studies. Each vial contains 100 µl of antiserum, providing enough volume for multiple western blot membranes and several immunohistochemistry runs once optimal working dilutions are determined empirically.

Supplied at 100 µl per vial, the antibody is intended for research use only and should be handled using standard immunoreagent practices, including brief centrifugation before opening and aliquoting to limit repeated freeze-thaw exposure during long-term storage.