Anti-TTK Antibody

TTK (also called Mps1) is a dual-specificity protein kinase that operates as a core component of the spindle assembly checkpoint, ensuring faithful chromosome segregation during mitosis. Aberrant TTK expression has been linked to aneuploidy and tumor progression, which has made it a focal target in cancer biology and small-molecule kinase inhibitor discovery.

This rabbit polyclonal antibody from Antibodies.com is supplied as an unconjugated reagent in a 100 µl volume, validated for Western blot (WB) and immunohistochemistry (IHC) workflows. The polyclonal format recognizes multiple epitopes across TTK, which can improve detection in samples where post-translational modification or splice variation might mask a single binding site.

Reactivity has been confirmed against human, mouse, and rat TTK, supporting work across cell line panels, patient-derived tissue, and rodent disease models. Common research applications include profiling TTK levels in mitotic cell populations, examining tumor biopsies for kinase overexpression, and supporting compound screening assays in which TTK inhibition is read out by Western blot of phospho-substrates.

For handling, a brief centrifugation before opening recovers any material that may have settled, and the reagent should be stored frozen in single-use aliquots to limit repeated freeze-thaw cycles that erode polyclonal titer.