Anti-TSPO Antibody [Assigned #A10765]

This unconjugated rabbit monoclonal antibody from Antibodies.com targets TSPO (Translocator Protein 18 kDa), a five-transmembrane-domain protein that resides mainly in the outer mitochondrial membrane where it participates in cholesterol translocation into mitochondria, a rate-limiting step in steroidogenesis, and modulates mitochondrial bioenergetics and apoptosis signaling. The reagent is supplied as a 50 µl liquid aliquot of IgG, raised against a defined epitope and validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows on human and mouse samples. Because TSPO expression rises sharply in activated microglia and in steroidogenic tissues, this reagent is widely used to map neuroinflammatory responses in models of neurodegeneration, traumatic brain injury, and glioma, as well as to characterize Leydig cell and adrenal cortex steroidogenic capacity. The unconjugated format allows flexible pairing with user-selected secondary reagents, fluorophores, or HRP conjugates. Researchers studying translocator protein function rely on this clone to distinguish mitochondrial fractions in subcellular localization studies and to probe changes in microglial activation states in fixed tissue sections.