Anti-TSHB Antibody

Raised in rabbit as a polyclonal reagent, this unconjugated primary antibody targets the beta subunit of human thyrotropin, the pituitary glycoprotein hormone that governs thyroid hormone production via the TSH receptor on thyroid follicular cells. The reagent is supplied by Antibodies.com at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol cryoprotectant, packaged as a 100 µl vial suitable for Western blot, immunohistochemistry, and immunofluorescence workflows. It binds the TSHB polypeptide expressed by thyrotroph cells of the anterior pituitary and supports studies of central hypothyroidism, pituitary transcription factor networks, and feedback within the hypothalamic-pituitary-thyroid axis. Because the beta subunit confers biological specificity on the heterodimeric TSH hormone, distinguishing it from the shared alpha subunit found in LH, FSH, and hCG, selective detection is useful when dissecting thyrotroph-specific signaling or characterizing pituitary adenomas. Researchers investigating congenital central hypothyroidism arising from TSHB loss-of-function variants, or mapping regulators such as POU1F1 and GATA2 that govern thyrotroph differentiation, will find this antibody a focused reagent for human samples.