Anti-TSEN54 Antibody

The TSEN54 protein is a catalytic subunit of the tRNA splicing endonuclease complex, which removes introns from precursor tRNAs. Variants in TSEN54 are linked to pontocerebellar hypoplasia type 2 (PCH2) and related neurodevelopmental disorders, making this target relevant for research into cerebellar development and neurodegeneration.

Produced in rabbit as a polyclonal reagent, this unconjugated antibody from Antibodies.com is validated for Western blot (WB) and immunohistochemistry (IHC) on human and mouse samples. Each vial contains 100 µL of the antibody, providing multiple epitope recognition across the TSEN54 protein for detection in whole-cell lysates, tissue homogenates, and fixed tissue sections.

For Western blot, the reagent enables probing of endogenous TSEN54 expression across cell lines and primary tissues. In IHC, it supports visualization of TSEN54 distribution in brain sections, useful for studies of PCH pathology and tRNA processing biology. Store refrigerated and aliquot to limit freeze-thaw cycles, in line with typical polyclonal antibody handling.