Anti-TRPM5 Antibody

This polyclonal antibody from Antibodies.com targets TRPM5 (Transient Receptor Potential Melastatin 5), a calcium-activated non-selective cation channel that plays a critical role in taste transduction and chemosensory signaling. TRPM5 is highly expressed in Type II taste receptor cells of the lingual taste buds, where it mediates responses to sweet, umami, and bitter stimuli downstream of TAS1R and TAS2R receptors.

Beyond gustatory function, TRPM5 is also detected in pancreatic beta cells, the olfactory epithelium, and certain enteroendocrine cells, making this reagent useful for studies on glucose-stimulated insulin secretion and metabolic regulation. The antibody is raised in rabbit and supplied as an unconjugated polyclonal reagent in a 100 µl volume suitable for western blot and immunohistochemistry workflows.

Reactivity has been validated against human and mouse samples, supporting cross-species investigations in taste biology, metabolic disease models, and sensory neuroscience research. The unconjugated format allows flexible pairing with custom fluorophores or HRP conjugates depending on the chosen detection method.