Anti-TRPM2 Antibody

Raised in rabbit against the human TRPM2 (transient receptor potential melastatin 2) non-selective, calcium-permeable cation channel, this unconjugated polyclonal primary antibody from Antibodies.com supports research into oxidative-stress-driven cell death and calcium signaling. The TRPM2 channel carries a C-terminal NUDIX hydrolase domain that confers responsiveness to intracellular ADP-ribose, and it is widely investigated in the contexts of parthanatos, ischemia-reperfusion injury, neuroinflammation, and immune-cell activation.

Validated by Antibodies.com for Western blot, immunohistochemistry, and immunofluorescence workflows on human samples, the reagent enables protein-level detection of TRPM2 in lysates, fixed tissue sections, and cultured cells. Researchers commonly deploy it to map channel localization in neurons, microglia, and granulocytes, and to probe changes in TRPM2 expression in neurodegenerative and inflammatory disease models.

The antibody is supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, a buffer combination that limits microbial growth and preserves activity during storage at -20 °C. Aliquoting on first thaw is recommended to keep freeze-thaw cycles to a minimum and protect the product for downstream assay work.