Anti-TRMT11 Antibody

TRMT11 is a 2'-O-methyltransferase that catalyzes Um44 formation on the variable loop of substrate tRNAs, acting in a functional heterodimer with the auxiliary factor TRMT112. This unconjugated rabbit polyclonal primary antibody from Antibodies.com enables detection of TRMT11 protein in human, mouse, and rat samples by Western blot (WB), and is supplied as 100 µL at 1 mg/ml in phosphate buffered saline (PBS) with 15 mM sodium azide at approximately pH 7.2.

Researchers investigating tRNA modification biology, codon-specific translation regulation, and the epitranscriptome use anti-TRMT11 reagents to track expression of the catalytic enzyme across cell lines and tissue lysates. The polyclonal antibody format provides multi-epitope recognition that improves signal consistency in denatured SDS-PAGE immunoblotting workflows, and previous studies have linked altered TRMT11 activity to hepatocellular carcinoma biology as well as to broader patterns of codon-biased translation.

The unconjugated format allows end users to pair the antibody with HRP-conjugated, fluorescent, or biotinylated secondary reagents as their workflow requires. Aliquot upon first use to limit freeze-thaw cycles of the stock vial; the 15 mM sodium azide acts as a microbial preservative in the working solution. For research use only in studies of RNA modification, ribosome function, and translation fidelity.