Anti-Trk A Antibody

Produced in rabbit and supplied as a 100 µl vial of unconjugated polyclonal antiserum, this reagent from Antibodies.com specifically targets TrkA (NTRK1), the high-affinity transmembrane tyrosine kinase receptor for nerve growth factor (NGF). TrkA signaling governs the differentiation, survival, and programmed cell death of sympathetic and sensory neurons, and the same receptor is clinically relevant in oncology because activating NTRK1 gene fusions drive a recognized subset of pediatric and adult solid tumors, including secretory breast carcinoma, papillary thyroid carcinoma, and certain soft tissue sarcomas.

Recommended for Western blot (WB), immunohistochemistry (IHC), and ELISA workflows, the antibody cross-reacts with human, mouse, and rat TrkA and supports translational studies in cell line, tissue section, and lysate preparations from each species. Researchers apply it to map TrkA distribution in dorsal root ganglion and central nervous system tissue, to probe NGF-dependent downstream phosphorylation cascades, and to characterize TRK inhibitor response in NTRK1 fusion-positive tumor samples. The polyclonal format recognizes multiple epitopes across the receptor, which is helpful when working with truncated fusion variants, splice isoforms, or post-translationally modified receptor populations.

For handling, store at -20 °C in single-use aliquots to limit freeze-thaw cycles and preserve lot-to-lot activity. The unconjugated format gives laboratories freedom to conjugate the antibody to their preferred reporter for custom immunofluorescence, chromogenic, or bead-based detection assays.