Anti-TRIM63 Antibody

This Rabbit polyclonal antibody from Antibodies.com recognises TRIM63, the E3 ubiquitin ligase also known as MuRF1 that flags myofibrillar proteins for ubiquitination and proteasomal turnover in striated muscle. Researchers use it in western blot, immunohistochemistry, and immunofluorescence workflows to track TRIM63 expression across cardiac and skeletal muscle tissue under atrophy, hypertrophy, and remodelling conditions.

Supplied as 100 µL of unconjugated polyclonal sera raised in Rabbit, the reagent can be paired with labelled secondary antibodies of choice for multiplex detection. Reactivity has been confirmed in Human, Mouse, and Rat samples, supporting translational studies that span rodent disease models and human biopsy material.

Typical investigative uses include profiling MuRF1 induction in disuse atrophy, cancer cachexia, age-related sarcopenia, pressure-overload heart failure, and exercise interventions, where TRIM63 protein levels serve as a readout of ubiquitin-proteasome-driven muscle proteolysis.