Anti-TRIM54 Antibody

Primary Antibodies from Antibodies.com targeting TRIM54, a muscle-specific E3 ubiquitin ligase of the tripartite motif family also known as MURF-3 and RNF30. This rabbit polyclonal IgG reagent, supplied as 200 µl of unconjugated antiserum, supports Western blot and immunohistochemistry workflows on human samples. TRIM54 participates in sarcomere assembly through interactions with titin and other contractile proteins, and its expression is largely restricted to skeletal and cardiac muscle, where it contributes to myofibril organization, muscle differentiation, and the regulation of protein turnover via the ubiquitin–proteasome pathway. Researchers studying striated muscle development, cardiac hypertrophy, atrophy signaling, or neuromuscular disease can use the antibody to detect endogenous TRIM54 in cell lysates and tissue sections. The polyclonal format broadens epitope coverage across the antigen, which is useful when probing post-translationally modified or alternatively spliced forms of the protein in differentiated myotubes and adult tissue preparations.