Anti-TRIM5 Antibody

A rabbit polyclonal antibody from Antibodies.com, raised against TRIM5 (Tripartite Motif Containing 5), a cytoplasmic E3 ubiquitin ligase that recognizes retroviral capsid lattices and accelerates their premature disassembly during early infection. This unconjugated reagent is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial for refrigerated storage.

Validated for Western blot and immunohistochemistry workflows on human, mouse, and rat samples, the polyclonal format allows detection of multiple epitopes across the TRIM5 protein, useful when studying innate immune restriction of HIV-1 and other retroviruses in primary cells, tissue sections, and whole-cell lysates. Researchers working on pattern recognition receptors, post-entry restriction, and comparative restriction factor biology will find this reagent a flexible primary detection tool, with the unconjugated format enabling pairing with custom HRP, fluorophore, or biotin secondary labels to match chemiluminescence, fluorescence, and chromogenic protocols.