Anti-TRIM49 Antibody

Raised in rabbit against the human tripartite motif-containing protein 49, this unconjugated polyclonal reagent from Antibodies.com is supplied as a 100 µL liquid aliquot and is validated for western blot and immunohistochemistry on human specimens. TRIM49 belongs to the TRIM family of E3 ubiquitin ligases, which are defined by their RING, B-box, and coiled-coil domain architecture and play roles in innate immunity, antiviral defense, and ubiquitin-dependent protein turnover. The protein is preferentially expressed in testis, where it contributes to spermatogenesis, and it has been mapped to chromosome 11q14.3. For short-term handling keep refrigerated; for extended storage, freeze at -20 degrees C in working aliquots to minimize freeze-thaw cycles. Researchers investigating reproductive biology, host-pathogen interactions, or post-translational regulation by the ubiquitin-proteasome system can use this vial to detect endogenous TRIM49 in cell lysates, tissue cryosections, and formalin-fixed paraffin-embedded (FFPE) samples. The antibody is for research use only and is not intended for diagnostic or therapeutic applications.