Anti-TRIM33 Antibody [Assigned #A9919]

The TRIM33 target (Tripartite Motif Containing 33), also known as TIF1γ or Ectodermin, is an E3 ubiquitin ligase that functions as a transcriptional regulator and modulator of TGF-β signaling. This Mouse monoclonal IgG reagent from Antibodies.com is supplied as a 100 µl unconjugated liquid, validated for Western blot detection of endogenous human TRIM33 protein.

Application-relevant attributes include a Mouse host, monoclonal IgG isotype, an unconjugated format that supports flexible downstream conjugation, reactivity confirmed against human samples, and intended use in Western blot. Each vial provides 100 µl of purified antibody, sufficient for multiple blot experiments depending on dilution.

Background: TRIM33 (TIF1gamma) acts as a tumor suppressor in several cancer contexts, ubiquitinates SMAD4 to fine-tune TGF-β pathway output, and contributes to chromatin remodeling at DNA damage sites. Researchers commonly use this reagent to monitor expression changes following genotoxic stress, pathway modulation, or differentiation cues in cell culture models. Store refrigerated; aliquot upon receipt, protect from light to preserve activity, and avoid repeated freeze-thaw cycles. The unconjugated format allows direct conjugation to HRP, biotin, or fluorophore labels of choice.