Anti-TRIM33 Antibody

This rabbit polyclonal IgG antibody from Antibodies.com targets TRIM33 (Tripartite Motif Containing 33), a member of the tripartite motif (TRIM) family of E3 ubiquitin ligases also known as TIF1-gamma and ectodermin. The unconjugated reagent is supplied as 200 µl of liquid and is validated for Western blot detection of the human protein in cell and tissue lysates.

TRIM33 participates in transcriptional regulation through the TGF-beta signaling pathway, where it ubiquitinates SMAD4 to control receptor-activated SMAD complex activity. It also contributes to chromatin remodeling, the DNA damage response, and acts as a tumor suppressor in several tissue contexts, making it a target of interest for cancer biology and signal transduction studies.

Raised in rabbit, this polyclonal IgG antibody is commonly used to probe TRIM33 expression in human cell lines by Western blot, often to investigate its role in hematopoiesis, transcription factor regulation, and ubiquitin-mediated protein turnover. Refrigerate the antibody at 4°C in single-use aliquots to preserve activity across multiple freeze-thaw cycles.