Anti-TRIM21 Antibody

The Antibodies.com Anti-TRIM21 polyclonal antibody is raised in rabbit and specifically detects the human TRIM21 protein, an E3 ubiquitin-protein ligase that contributes to innate immunity and autoimmunity research. TRIM21 functions as a cytosolic Fc receptor that binds antibody-coated pathogens and channels them into the ubiquitin-proteasome degradation pathway, making it a frequent subject in intracellular antibody neutralization studies.

Supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol cryoprotectant, this unconjugated reagent is validated for Western blot and immunohistochemistry on human samples. For research use only, the antibody supports investigation of Sjögren's syndrome, systemic lupus erythematosus, and dermatomyositis, where circulating anti-Ro52/TRIM21 autoantibodies serve as clinical biomarkers of disease activity.

The polyclonal format provides multi-epitope recognition, which tends to yield stronger and more consistent signals in IHC tissue staining. Store at -20 °C; the glycerol formulation protects against freeze-thaw damage, and working aliquots should be refrigerated to preserve binding activity. This primary antibody fits ubiquitination pathway research, autoantibody screening, and broader immunology workflows where detection of endogenous human TRIM21 is required.