Anti-Tricyclic Antidepressant (TCA) Antibody

Purified mouse monoclonal reagent from Antibodies.com that recognizes tricyclic antidepressants, a class of psychoactive agents comprising amitriptyline, nortriptyline, imipramine, desipramine, and clomipramine. Cloned as an IgG1, kappa immunoglobulin and supplied unconjugated at 1 mg per vial, the antibody underpins ELISA workflows used in therapeutic drug monitoring and forensic toxicology screening, where rapid class-level identification of TCA exposure informs clinical decisions during suspected overdose and supports dose adjustments in chronic treatment regimens. The reagent binds the shared tricyclic core scaffold rather than any single member, which gives laboratories a single assay component that flags exposure to the broader drug class without requiring separate antibodies per compound. Because the paratope is delivered without an attached reporter, end users retain full flexibility to conjugate horseradish peroxidase, alkaline phosphatase, biotin, or fluorophores themselves, so the same lot can move between competitive ELISA plates, lateral flow strips, and immunoaffinity columns without changes in binding behavior. The IgG1, kappa constant region is also compatible with standard anti-mouse secondary reagents across western blot and immunohistochemistry platforms, broadening downstream assay options without further purification steps.