Anti-TRF1 (phospho-S219) Antibody

Affinity-purified rabbit polyclonal reagent raised against a phosphorylated epitope of human telomeric repeat-binding factor 1 (TRF1/TERF1), specifically recognizing the serine 219 phospho-site. TRF1 is a core component of the shelterin complex that caps chromosome ends and regulates telomere length, and phosphorylation at S219 has been linked to ATM-dependent signaling during the DNA damage response and to CDK-driven S-phase progression. This unconjugated antibody from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a 100 µl aliquot, validated for Western blot detection of endogenous TRF1 in human, mouse, and rat samples. Researchers investigating telomere maintenance, genomic stability, replicative senescence, and oncogenic transformation commonly probe phospho-S219 TRF1 levels to monitor shelterin disruption following genotoxic stress or replication fork stalling. The 50% glycerol cryoprotectant formulation permits convenient frozen storage with minimal freeze-thaw damage to the active antibody.