Anti-TRAP220 Antibody

Produced in rabbit and validated for western blot, immunohistochemistry, and ELISA, this unconjugated polyclonal antibody from Antibodies.com recognizes TRAP220 (also called Mediator complex subunit 1, MED1), a transcriptional coactivator within the Mediator complex that links DNA-bound transcription factors to the basal RNA polymerase II machinery. Supplied as a 100 µl aliquot, the reagent has been tested for reactivity against human and mouse samples.

TRAP220/MED1 is a key coactivator for nuclear hormone receptors, including the thyroid hormone receptor, retinoic acid receptor, estrogen receptor, and PPAR gamma, where it mediates ligand-dependent transcriptional activation. Research applications include investigation of nuclear receptor signaling in adipogenesis, mammary gland development, and hormone-responsive cancer biology. The polyclonal format provides recognition of multiple epitopes on the approximately 220 kDa target. For storage, aliquot the antibody and freeze at -20 degrees C to limit freeze-thaw cycles; protect from light during handling and avoid prolonged room temperature exposure.