Anti-Transglutaminase 2 Antibody

Targeting tissue transglutaminase (TG2), this polyclonal reagent raised in rabbit supports protein-level detection in human samples across western blot and immunohistochemistry workflows. Supplied as 100 µl of unconjugated antisera, it binds the TG2 enzyme that catalyzes calcium-dependent crosslinking of glutamine residues with lysine side chains, a modification implicated in celiac disease autoimmunity, extracellular matrix stabilization during wound healing, and the formation of insoluble protein aggregates in neurodegenerative tissue.

The antibody is validated for immunoblotting of cell and tissue lysates and for chromogenic or fluorescent staining of formalin-fixed, paraffin-embedded sections, enabling localization studies in epithelial, endothelial, and neuronal contexts. Researchers investigating celiac serology, fibrosis, cancer cell migration, or polyglutamine expansion disorders can apply it as a primary detection reagent alongside standard HRP- or fluorophore-conjugated secondary antibodies. Refrigerated storage is recommended between uses to preserve activity, with brief equilibration to room temperature prior to dilution, and aliquoting upon arrival helps limit freeze-thaw cycles. Antibodies.com provides this reagent as a single-vial, ready-to-aliquot format that fits routine bench protocols.