Anti-TRAF3 Antibody

TRAF3 (TNF receptor-associated factor 3) is a cytoplasmic adaptor protein that regulates signaling downstream of multiple receptor families, including TNF receptors, Toll-like receptors, and the T-cell receptor. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against human TRAF3 and is validated for western blot and immunohistochemistry on human samples. The reagent is supplied at 100 µl, providing enough material for multiple immunoblotting rounds and staining procedures. TRAF3 serves as a negative regulator of NF-κB non-canonical signaling and as a positive driver of type I interferon production, with germline variants linked to herpes simplex encephalitis and somatic alterations implicated in B-cell lymphoma biology. Investigators studying innate immunity, B-cell maturation, or viral susceptibility pathways routinely deploy this reagent to probe endogenous TRAF3 expression across cultured cell lysates and formalin-fixed tissue sections.