Anti-TRAF3 Antibody

Used to detect endogenous and overexpressed TRAF3 in cell lysates and tissue sections, this unconjugated rabbit polyclonal antibody from Antibodies.com is supplied as a 100 µl vial at 1 mg/ml in PBS with 0.1% Sodium Azide and 50% Glycerol. It is validated for Western blot, immunohistochemistry, and immunofluorescence work in human and mouse samples.

TRAF3 (TNF Receptor Associated Factor 3) operates as a multifunctional E3 ubiquitin ligase and signaling adaptor, suppressing non-canonical NF-κB activation by targeting NIK for degradation while promoting type I interferon responses downstream of Toll-like receptors and cytosolic nucleic acid sensors. Loss-of-function mutations and deletions of TRAF3 are recurrent in B-cell malignancies, making reliable detection of this protein central to lymphoma and immune signaling research.

The polyclonal rabbit host recognizes multiple epitopes across the TRAF3 sequence, providing broader coverage than monoclonal alternatives. Store frozen at -20 °C in single-use aliquots to limit freeze-thaw cycles, and protect the vial from light. The glycerol-containing PBS formulation maintains antibody activity under standard laboratory freezer conditions.