Anti-TRAF2 Antibody

This polyclonal antibody from Antibodies.com targets TRAF2 (TNF Receptor-Associated Factor 2), an E3 ubiquitin ligase and adapter protein central to signal transduction from the TNF receptor superfamily. Produced in rabbit and supplied as an unconjugated reagent in a 100 µl vial, the antibody is validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows on samples from human, mouse, and rat origins.

TRAF2 mediates recruitment of downstream effectors that activate NF-κB and JNK pathways, making it a frequent target in studies of inflammation, apoptosis, immune cell signaling, and stress-activated kinase cascades. The reagent is recommended for storage at -20°C in working aliquots to limit freeze-thaw cycles and protect from repeated temperature shifts.

Researchers investigating TNFR1/TNFR2 complex assembly, RIP1 ubiquitination, or B-cell and T-cell receptor cross-talk rely on TRAF2-specific antibodies to map scaffold functions and post-translational modifications. The polyclonal format yields recognition of multiple epitopes across the TRAF2 sequence, supporting consistent band detection near the expected 56-58 kDa molecular weight in western blot of whole-cell lysates.