Anti-TPP1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets tripeptidyl peptidase 1 (TPP1), a lysosomal serine protease that sequentially removes N-terminal tripeptides from polypeptides during lysosomal protein turnover. TPP1 loss-of-function is the molecular basis of CLN2 disease, also called neuronal ceroid lipofuscinosis type 2, so the reagent supports neuroscience and lysosomal-storage research alongside broader cell biology studies of intracellular protein degradation pathways.

The product is supplied as 100 µl of unconjugated rabbit antisera and is validated for western blot (WB) and immunohistochemistry (IHC) applications on human, mouse, and rat samples. Polyclonal reactivity broadens epitope coverage, which can be useful when distinguishing full-length TPP1 from the smaller processed forms generated as the proenzyme matures inside the lysosome.