Anti-TPMT Antibody

Raised in rabbit against Thiopurine Methyltransferase (TPMT), this unconjugated polyclonal antibody from Antibodies.com is supplied as 100 µl of ready-to-use reagent validated for Western blot and immunohistochemistry workflows. Reactivity has been confirmed against human, mouse, and rat samples, supporting comparative work across cell lysates and fixed tissue sections in translational research programs.

TPMT is a cytoplasmic enzyme that S-methylates aromatic and heterocyclic thiopurine drugs such as azathioprine and 6-mercaptopurine, agents widely prescribed for acute lymphoblastic leukemia, inflammatory bowel disease, and autoimmune disorders. Inter-individual variation in TPMT activity is a clinically established predictor of myelosuppression risk, so antibody-based detection of endogenous expression supports pharmacogenomic screening, drug-response studies, and mechanistic toxicology investigations in preclinical disease models.

Prepared as an unconjugated rabbit polyclonal, the reagent is dispensed in a single 100 µl vial that pairs cleanly with HRP, biotin, or fluorophore-conjugated secondary systems chosen by the end user. Store refrigerated short term, aliquot upon first use to limit freeze-thaw cycling, and protect from light during handling. Intended for research use only; not for diagnostic or therapeutic application.