Anti-TPM2 Antibody

Raised in rabbit and supplied by Antibodies.com, this polyclonal reagent specifically targets beta-tropomyosin, the actin-binding protein product of the TPM2 gene that has been linked to nemaline myopathy, cap myopathy, and distal arthrogryposis type 1. The unconjugated preparation is delivered as 100 µl at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, validated for Western blot and immunohistochemistry on human and mouse specimens. Researchers investigating sarcomeric thin-filament dynamics, skeletal muscle differentiation, and cytoskeletal regulation use this reagent to detect endogenous TPM2 protein in cell lysates and fixed tissue sections. Its cross-reactivity profile covers both human and mouse samples, making it a practical choice for comparative studies of striated muscle development and actin filament organization. To preserve binding activity, aliquot upon arrival and store at -20°C, limiting the number of freeze-thaw cycles; the included glycerol serves as a cryoprotectant for routine handling. The polyclonal format provides recognition of multiple epitopes on the target, which can be helpful when probing denatured proteins on membranes or fixed antigens in tissue sections.