Anti-TPM1 Antibody

TPM1 (tropomyosin 1 alpha) is an actin-binding protein that stabilizes cytoskeletal filaments and plays a structural role in striated and smooth muscle contraction. This unconjugated rabbit polyclonal reagent from Antibodies.com targets TPM1 for detection in western blot, immunohistochemistry, and immunofluorescence workflows, supporting studies of sarcomeric assembly, cytoskeletal remodeling, and isoform switching in cardiac and skeletal muscle tissues.

The antibody has been validated on human, mouse, and rat samples, enabling cross-species comparisons in cancer cell models where TPM1 has been implicated as a tumor suppressor, as well as in cardiomyocyte differentiation and smooth muscle gene regulation. The reagent is supplied at 100 µl per vial, sufficient for multiple replicate blots or staining runs, and is provided as a polyclonal antiserum without fluorophore or enzyme conjugation, so it can be paired with a secondary antibody matched to the chosen detection chemistry.

For best results, store aliquots refrigerated, protect from light, and avoid repeated freeze-thaw cycles to preserve binding activity over the working shelf life. Intended for research use only in laboratory applications such as western blot, immunohistochemistry, and immunofluorescence on fixed cells or tissue sections.