Anti-TP53INP2 Antibody

This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is raised against TP53INP2 (tumor protein p53-inducible nuclear protein 2), a nuclear and cytoplasmic regulator of autophagy also known as DOR. The antibody is affinity-purified and binds an epitope conserved across the human target with demonstrated cross-reactivity to the mouse and rat orthologs, making it a practical reagent for translational autophagy research.

Validated for Western blot, the antibody is supplied as 100 µl of a 1 mg/ml stock in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.3. Sodium azide is included as a microbial preservative; researchers planning azide-sensitive downstream steps should buffer-exchange the reagent before use.

TP53INP2 participates in starvation-induced autophagy, controls the subcellular distribution of transcription factors including thyroid hormone receptors and PPARs, and has been implicated in glucose homeostasis, lipid droplet turnover, and cellular stress responses. Published studies have used anti-TP53INP2 antibodies to monitor autophagosome formation, map interactions with Beclin-1 and LC3 conjugation machinery, and probe the protein's role in cancer cell survival, neuronal stress, and metabolic disease models. The polyclonal format offers an epitope-broad detection profile that tolerates minor sequence variation between species, supporting consistent comparison across human, mouse, and rat samples in immunoblotting experiments.