Anti-TP53INP1 Antibody

For Western blot workflows, this rabbit polyclonal reagent from Antibodies.com detects endogenous TP53INP1 across human, mouse, and rat samples. TP53INP1 is a stress-inducible nuclear protein that partners with p53 to drive transcription of pro-apoptotic target genes, and it also regulates autophagosome maturation through interactions with LC3 family members. Researchers studying DNA damage responses, oxidative stress signaling, and tumor suppression pathways frequently probe TP53INP1 levels to track p53 activity or autophagy flux in cell lysates.

The IgG antibody is supplied as a 200 µl vial of unconjugated sera, ready to pair with HRP-, fluorophore-, or biotin-conjugated secondary reagents depending on the chosen detection chemistry. Because the host species is rabbit, anti-rabbit IgG secondaries provide clean signal on WB membranes with minimal background. The polyclonal format increases the chance of recognizing multiple epitopes on TP53INP1, which is helpful when probing the protein in tissues where the two known isoforms (TP53INP1α and TP53INP1β) are expressed at different levels.

Storage at -20 °C in working aliquots is recommended to preserve activity across freeze-thaw cycles. The reagent is intended for research use only and is not approved for diagnostic or therapeutic applications. Investigators working on tumor biology, neurodegeneration, or metabolic disease models will find this tool relevant for dissecting how TP53INP1 contributes to stress responses and cell fate decisions.