Anti-TP53BP2 Antibody

Raised in rabbit against the human TP53BP2 protein, this polyclonal antibody from Antibodies.com enables detection of the apoptosis-stimulating p53-binding partner in western blot and immunohistochemistry workflows. TP53BP2, also referred to as ASPP2, functions as a regulator of p53-mediated apoptosis and has been studied in the context of DNA damage response, tumor suppression, and stress-induced signaling pathways.

The reagent is supplied as 100 µL of a 1 mg/mL stock prepared in PBS with 0.1% sodium azide and 50% glycerol, with the unconjugated format allowing users to choose their own detection label or secondary system. The antibody is reactive with human samples and has been validated for WB and IHC applications. Glycerol in the buffer permits storage at −20 °C and protects activity through repeated freeze-thaw cycles; small aliquots can be made from the original vial to limit handling of the stock.

Because TP53BP2 is expressed across a spectrum of human tissues and cell lines, researchers commonly apply this reagent to lysates from cancer cell models and to fixed tissue sections to investigate ASPP2 expression patterns. The polyclonal nature of the reagent supports recognition of multiple epitopes on the target, which can be useful when probing full-length TP53BP2 or isoforms of interest.