Anti-TP53BP1 Antibody

The TP53BP1 protein, also called 53BP1, is a central mediator of the cellular DNA damage response that is rapidly recruited to chromatin flanking double-strand breaks, where it acts as a barrier to homologous recombination and channels repair toward non-homologous end joining. This rabbit polyclonal reagent from Antibodies.com targets a region of TP53BP1 conserved across human, mouse, and rat orthologs, enabling consistent detection in translational studies that span rodent models and patient-derived samples.

Validated for Western blot, immunohistochemistry, and immunofluorescence, the unconjugated antibody is supplied as 100 µl of polyclonal antiserum fraction from a rabbit host. Researchers working on ATM/ATR signaling, BRCA1-deficient tumor contexts, chromatin remodeling at break sites, class switch recombination, V(D)J recombination, and p53 pathway biology routinely use this reagent to monitor 53BP1 focus formation, phosphorylation events at DNA damage sites, and recruitment kinetics at laser micro-irradiation tracks. Storage at -20 °C in working aliquots preserves activity for repeated experiments and minimizes freeze-thaw loss of titer across multi-week study timelines.