Anti-TP53 (phospho S15) Antibody

Phosphorylation of the p53 tumor suppressor at serine 15 is a hallmark of the cellular DNA damage response, primarily mediated by ATM kinase following double-strand DNA breaks. This unconjugated rabbit polyclonal IgG antibody from Antibodies.com is raised against the phospho-S15 epitope of human TP53, enabling researchers to distinguish the activated, phosphorylated form of p53 from total p53 in cell lysates.

Validated for Western blot, the reagent is supplied as a 50 µl aliquot and supports studies of genotoxic stress, apoptosis induction, ATM/ATR signaling cascades, and p53 pathway activation in cancer biology and DNA repair research. As an unconjugated primary antibody, it pairs flexibly with HRP-, fluorophore-, or biotin-labeled secondary reagents, allowing researchers to tailor detection chemistry to their experimental workflow. The antibody is reactive with human samples and intended for research use only, making it a focused tool for interrogating site-specific post-translational modification of p53 in response to ionizing radiation, chemotherapeutic insult, or replication stress.