Anti-TP53 Antibody

Raised in rabbit against a conserved epitope of human TP53, this polyclonal primary antibody from Antibodies.com targets the p53 tumor suppressor and is validated for western blot and immunofluorescence workflows. The unconjugated reagent is supplied as 100 µl of antiserum and recognizes the full-length wild-type protein as well as commonly studied missense mutants, supporting work on DNA damage response, cell-cycle arrest, and apoptosis in transformed cell lines and primary cultures.

Characterized reactivity spans human and mouse samples, enabling parallel experiments in xenograft tumors, syngeneic models, and p53 knockout mice alongside patient-derived tissue. Researchers investigating p53 stabilization after genotoxic stress, MDM2-mediated degradation, or downstream transactivation of targets such as p21 and BAX routinely apply this reagent to whole-cell lysates for immunoblotting and to fixed cells for imaging of nuclear p53 accumulation.

Each vial should be aliquoted upon arrival and stored frozen to limit freeze-thaw cycles and preserve activity across long-running studies.