Anti-TP53 Antibody

A polyclonal reagent from Antibodies.com raised in rabbit hosts that recognizes TP53, the protein encoded by the TP53 tumor-suppressor gene. Supplied as an unconjugated IgG in a 50 µl volume, the antibody is listed for western blot and immunofluorescence workflows and cross-reacts with human, mouse, and rat specimens, supporting comparative studies across common laboratory species.

TP53 is a central effector of cellular stress pathways, integrating signals from DNA damage, oxidative stress, and oncogene activation to drive cell-cycle arrest, senescence, or apoptosis. Researchers use this reagent to probe steady-state TP53 abundance by western blot and to localize the protein within fixed cells or tissue sections by immunofluorescence, where nuclear accumulation after genotoxic insult is a classic experimental readout.

The unconjugated format lets investigators pair the primary with a laboratory-selected labeled secondary antibody for fluorescence, chemiluminescent, or chromogenic detection. Standard storage at -20 °C with aliquoting to avoid repeated freeze-thaw cycles preserves antibody activity across experiments. For research use only; not intended for diagnostic or therapeutic applications.