Anti-TOPBP1 Antibody

Raised in rabbit as a polyclonal reagent, this unconjugated primary antibody from Antibodies.com targets TOPBP1 (topoisomerase II-binding protein 1) and is supplied at 1 mg/ml in PBS buffer with 0.1% sodium azide and 50% glycerol.

Each vial contains 100 µl of antibody applicable across western blot, immunohistochemistry, and immunofluorescence workflows in human, mouse, and rat samples.

Researchers investigating DNA damage response, replication checkpoint signaling, ATR kinase activation, and BRCA1-dependent repair pathways use this reagent to probe TOPBP1 recruitment to stalled replication forks.

The BRCT-repeat architecture of TOPBP1 makes it a useful marker for studying S-phase stress and genomic instability in oncology research.

Short-term storage at 4°C is appropriate for working aliquots; for longer preservation, freezing at -20°C is recommended, with avoidance of repeated freeze-thaw cycles.

This is a research use only reagent, not intended for diagnostic or therapeutic applications.